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STX7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O15400 |
| Other Accession | O70257, O70439, Q3ZBT5, NP_003560.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29816 Da |
| Antigen Region | 47-73 aa |
| Gene ID | 8417 |
|---|---|
| Other Names | Syntaxin-7, STX7 |
| Target/Specificity | This STX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-73 amino acids from the N-terminal region of human STX7. |
| Dilution | FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STX7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STX7 |
|---|---|
| Function | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| Cellular Location | Early endosome membrane; Single- pass type IV membrane protein |
| Tissue Location | Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Syntaxin 7 is involved in the ordered fusion of endosomes and lysosomes with the phagosome, where phagocytic cells kill and degrade internalized foreign particles. Syntaxin 7 is found in late endosomes and lysosomes; whereas Syntaxin 12 is localized to the recycling endosome compartment, both are recruited to the phagosome. However, STX12 is acquired earlier before rapidly recycling off the phagosome, whereas STX7 is recruited later and continues to accumulate throughout the phagosome maturation process.
References
Prekeris, R., et al. Mol. Biol. Cell 10(11):3891-3908(1999)
Steegmaier, M., et al. J. Biol. Chem. 273(51):34171-34179(1998)
Wong, S.H., et al. J. Biol. Chem. 273(1):375-380(1998)
Wang, H., et al. Gene 199 (1-2), 39-48 (1997)
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