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SKOR1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | P84550 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 100 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SKOR1 |
| Epitope Specificity | 1-100/965 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the SKI family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LBXCOR1 is a 965 amino acid protein belonging to the SKI family. Localizing to nucleus, LBXCOR1 is highly expressed in the central nervous system (CNS) as well as developing spinal cord and adult brain and testis. LBXCOR1 contains a CH1 domain which is required for transcriptional repression and also acts as a transcriptional co-repressor of LBX1. LBXCOR1 additionally interacts with SMAD1, SMAD2 and SMAD3, and inhibits BMP signaling. Existing as three alternatively spliced isoforms, the gene encoding LBXCOR1 maps to human chromosome 15q23. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and consists of about 3% of the human genome. Angelman and Prader-Willi syndromes, as well as Tay-Sachs disease and Marfan syndorme, are all associated with mutations to chromosome 15. |
| Gene ID | 390598 |
|---|---|
| Other Names | SKI family transcriptional corepressor 1, Functional Smad-suppressing element on chromosome 15, Fussel-15, LBX1 corepressor 1, Ladybird homeobox corepressor 1, SKOR1, CORL1, FUSSEL15, LBXCOR1 |
| Target/Specificity | Present specifically in cerebellar Purkinje cells (at protein level). |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SKOR1 |
|---|---|
| Synonyms | CORL1, FUSSEL15, LBXCOR1 |
| Function | Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. |
| Cellular Location | Nucleus. |
| Tissue Location | Present specifically in cerebellar Purkinje cells (at protein level). |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP56721
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