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Contactin 6 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UQ52 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 109 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NB3 |
| Epitope Specificity | 85-200/1028 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Lipid-anchor, GPI-anchor (By similarity). |
| SIMILARITY | Belongs to the immunoglobulin superfamily. Contactin family.Contains 4 fibronectin type-III domains.Contains 6 Ig-like C2-type (immunoglobulin-like) domains. |
| SUBUNIT | Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Contactin 6 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein which functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. |
| Gene ID | 27255 |
|---|---|
| Other Names | Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6 |
| Target/Specificity | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CNTN6 |
|---|---|
| Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
| Tissue Location | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP56919
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