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APOBEC2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, FC, E |
|---|---|
| Primary Accession | Q9Y235 |
| Other Accession | Q3SYR3, NP_006780.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25703 Da |
| Antigen Region | 19-48 aa |
| Gene ID | 10930 |
|---|---|
| Other Names | Probable C->U-editing enzyme APOBEC-2, 354-, APOBEC2 |
| Target/Specificity | This APOBEC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human APOBEC2. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APOBEC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOBEC2 |
|---|---|
| Function | Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
| Tissue Location | Expressed exclusively in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
APOBEC2 belongs to the cytidine and deoxycytidylate deaminase family. It is probable C to U editing enzyme whose physiological substrate is not yet known. It does not display detectable apoB mRNA editing and has a low intrinsic cytidine deaminase activity.
References
Liao, W., et al. Biochem. Biophys. Res. Commun. 260(2):398-404(1999)
Oka, K., et al. J. Biol. Chem. 272(3):1456-1460(1997)
Lau, P.P., et al. Proc. Natl. Acad. Sci. U.S.A. 91(18):8522-8526(1994)
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