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LRRC32 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q14392 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LRRC32 |
| Epitope Specificity | 231-330/662 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. |
| SIMILARITY | Contains 20 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LRRC32 is a 662 amino acid single-pass type I membrane protein that contains 22 LRR repeats and is thought to be involved in platelet-endothelium interactions, as well as in the development of rare, benign hibernomas. The gene encoding LRRC32 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
| Gene ID | 2615 |
|---|---|
| Other Names | Transforming growth factor beta activator LRRC32, Garpin, Glycoprotein A repetitions predominant, GARP, Leucine-rich repeat-containing protein 32, LRRC32 {ECO:0000303|PubMed:19651619, ECO:0000312|HGNC:HGNC:4161} |
| Target/Specificity | Preferentially expressed in regulatory T-cells (T(regs)). |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | LRRC32 {ECO:0000303|PubMed:19651619, ECO:0000312|HGNC:HGNC:4161} |
|---|---|
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell surface |
| Tissue Location | Preferentially expressed in regulatory T-cells (Tregs). |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP57069
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