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Mannosidase II Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q16706 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 131 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Mannosidase II |
| Epitope Specificity | 351-450/1144 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus membrane; Single-pass type II membrane protein |
| SIMILARITY | Belongs to the glycosyl hydrolase 38 family. |
| SUBUNIT | Homodimer; disulfide-linked |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013] |
| Gene ID | 4124 |
|---|---|
| Other Names | Alpha-mannosidase 2, 3.2.1.114, Golgi alpha-mannosidase II, AMan II, Man II, Mannosidase alpha class 2A member 1, Mannosyl-oligosaccharide 1, 3-1, 6-alpha-mannosidase, MAN2A1, MANA2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | MAN2A1 |
|---|---|
| Synonyms | MANA2 |
| Function | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:P28494}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P28494} |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP57203
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