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MAN2A1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q16706 |
| Other Accession | NP_002363.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 131141 Da |
| Antigen Region | 456-482 aa |
| Gene ID | 4124 |
|---|---|
| Other Names | Alpha-mannosidase 2, Golgi alpha-mannosidase II, AMan II, Man II, Mannosidase alpha class 2A member 1, Mannosyl-oligosaccharide 1, 3-1, 6-alpha-mannosidase, MAN2A1, MANA2 |
| Target/Specificity | This MAN2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-482 amino acids from the Central region of human MAN2A1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAN2A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAN2A1 |
|---|---|
| Synonyms | MANA2 |
| Function | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:P28494}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P28494} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
References
Han, S., et al. Leuk. Res. 34(10):1271-1274(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhou, J.B., et al. Med. Sci. Monit. 16 (6), BR179-BR183 (2010) :
Miyagawa, H., et al. Rheumatology (Oxford) 47(2):158-164(2008)
Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :
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