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RAB30 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q15771 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RAB30 |
| Epitope Specificity | 131-203/203 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane. |
| SIMILARITY | Belongs to the small GTPase superfamily. Rab family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 27314 |
|---|---|
| Other Names | Ras-related protein Rab-30, RAB30 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | RAB30 (HGNC:9770) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22188167). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (PubMed:22188167). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (By similarity). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (PubMed:26771875). |
| Cellular Location | Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome membrane. Autolysosome membrane. Note=Localized to dynamic membranes fusing to and exiting from the Golgi apparatus (By similarity) Localized to group A Streptococcus (GAS)-containing autophagosome to autolysosome in GAS-infected epithelial cells (PubMed:26771875). Also colocalized with a starvation-induced autophagosome although not required for autophagosome formation during starvation (PubMed:26771875). {ECO:0000250|UniProtKB:Q923S9, ECO:0000269|PubMed:26771875} |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP57633
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