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AFTPH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q6ULP2 |
| Other Accession | Q80WT5, NP_001002243.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 102113 Da |
| Antigen Region | 844-871 aa |
| Gene ID | 54812 |
|---|---|
| Other Names | Aftiphilin, AFTPH, AFTH |
| Target/Specificity | This AFTPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 844-871 amino acids from the C-terminal region of human AFTPH. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AFTPH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFTPH |
|---|---|
| Synonyms | AFTH |
| Function | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Co-localizes with AP1G1/AP- 1 in the cytoplasm (PubMed:14665628, PubMed:15758025). Recruited to the perinuclear region by AP1G1/AP-1 (PubMed:15758025) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
AFTPH may play a role in membrane trafficking.
References
Lui-Roberts, W.W., et al. Mol. Biol. Cell 19(12):5072-5081(2008)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Hirst, J., et al. Mol. Biol. Cell 16(5):2554-2565(2005)
Burman, J.L., et al. FEBS Lett. 579(10):2177-2184(2005)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
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