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PAPD4 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q6PIY7 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PAPD4 |
| Epitope Specificity | 31-130/484 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
| SIMILARITY | Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. Contains 1 PAP-associated domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PAPD4 (Poly(A) RNA Polymerase D4, Non-Canonical) is a Protein Coding gene. GO annotations related to this gene include polynucleotide adenylyltransferase activity. An important paralog of this gene is ZCCHC6. |
| Gene ID | 167153 |
|---|---|
| Other Names | Poly(A) RNA polymerase GLD2, hGLD-2, 2.7.7.19, PAP-associated domain-containing protein 4, Terminal nucleotidyltransferase 2 {ECO:0000312|HGNC:HGNC:26776}, Terminal uridylyltransferase 2, TUTase 2, TENT2 (HGNC:26776) |
| Target/Specificity | Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TENT2 (HGNC:26776) |
|---|---|
| Function | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91YI6}. Nucleus {ECO:0000250|UniProtKB:Q91YI6} |
| Tissue Location | Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP57855
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