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RCN3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q96D15 |
| Other Accession | Q8BH97, Q2KJ39, NP_065701.2, I6L9G5 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37493 Da |
| Antigen Region | 134-163 aa |
| Gene ID | 57333 |
|---|---|
| Other Names | Reticulocalbin-3, EF-hand calcium-binding protein RLP49, RCN3 |
| Target/Specificity | This RCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human RCN3. |
| Dilution | WB~~1:2000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RCN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCN3 (HGNC:21145) |
|---|---|
| Function | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant- associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). |
| Cellular Location | Endoplasmic reticulum lumen |
| Tissue Location | Widely expressed.. |
Provided below are standard protocols that you may find useful for product applications.
Background
Calcipressin 3 inhibits calcineurin dependent transcriptional responses by binding to the catalytic domain of calcineurin A, and may play a role during central nervous system development. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes.
References
Tsuji, A., et al. Biochem. J. 396(1):51-59(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
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