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TNFRSF19 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9NS68 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TROY |
| Epitope Specificity | 102-200/423 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single-pass type I membrane protein. |
| SIMILARITY | Contains 3 TNFR-Cys repeats. |
| SUBUNIT | Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TROY is a member of the TNF receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate the JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Gene ID | 55504 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 19, TRADE, Toxicity and JNK inducer, TNFRSF19, TAJ, TROY |
| Target/Specificity | Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TNFRSF19 |
|---|---|
| Synonyms | TAJ, TROY |
| Function | Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP58100
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