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COL4A3BP Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9Y5P4 |
| Reactivity | Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human COL4A3BP |
| Epitope Specificity | 551-624/624 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Golgi apparatus. Endoplasmic reticulum. |
| SIMILARITY | Contains 1 PH domain. Contains 1 START domain. |
| SUBUNIT | Interacts with COL4A3. Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA. |
| Post-translational modifications | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | COL4A3BP is a kinase that specifically phosphorylates the N terminal region of the non collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Two transcripts exist for this gene. |
| Gene ID | 10087 |
|---|---|
| Other Names | Ceramide transfer protein {ECO:0000303|PubMed:14685229, ECO:0000305}, hCERT, Collagen type IV alpha-3-binding protein, Goodpasture antigen-binding protein, GPBP, START domain-containing protein 11, StARD11, StAR-related lipid transfer protein 11, CERT1 (HGNC:2205) |
| Target/Specificity | Widely expressed. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CERT1 (HGNC:2205) |
|---|---|
| Function | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
| Cellular Location | Cytoplasm. Golgi apparatus. Endoplasmic reticulum Note=Preferentially localized to the Golgi apparatus |
| Tissue Location | Widely expressed. |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58267
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