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Hyaluronidase3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O43820 |
| Reactivity | Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46501 Da |
| Gene ID | 8372 |
|---|---|
| Other Names | Hyaluronidase-3, Hyal-3, 3.2.1.35, Hyaluronoglucosaminidase-3, Lung carcinoma protein 3, LuCa-3, HYAL3, LUCA3 |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=2ug/Test,IF=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | HYAL3 |
|---|---|
| Synonyms | LUCA3 |
| Function | Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q8VEI3}. Cell membrane {ECO:0000250|UniProtKB:Q8VEI3}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8VEI3}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VEI3}. Early endosome {ECO:0000250|UniProtKB:Q8VEI3}. Note=Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail. {ECO:0000250|UniProtKB:Q8VEI3} |
| Tissue Location | Expressed in sperm (PubMed:20586096). Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level) (PubMed:21699545). Bone marrow, testis and kidney (PubMed:10493834) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP58341
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