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BAI2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | O60241 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 169 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human BAI2 |
| Epitope Specificity | 701-800/1585 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell Membrane |
| SIMILARITY | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 4 TSP type-1 domains. |
| SUBUNIT | Interacts with GABPB2 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. |
| Gene ID | 576 |
|---|---|
| Other Names | Adhesion G protein-coupled receptor B2, Brain-specific angiogenesis inhibitor 2, ADGRB2 (HGNC:944), BAI2 |
| Target/Specificity | Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ADGRB2 (HGNC:944) |
|---|---|
| Synonyms | BAI2 |
| Function | Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Secreted |
| Tissue Location | Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines |
Research Areas
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$ 385.00
Cat# AP58671
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