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CCDC68 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9H2F9 |
| Reactivity | Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from Human CCDC68/se57-1 |
| Epitope Specificity | 255-335/335 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CCDC68, also known as CTCL tumor antigen se57-1, is a 335 amino acid protein expressed in cutaneous T-cell lymphoma (CTCL), bone marrow, colon, small intestine, spleen, testis and trachea tissues. CTCL is a cancer of the immune system associated with mutation of the T cells. Malignant T cells form lesions on the surface of the skin. se57-1 contains 1 coiled coil domain and is encoded by the CCDC68 gene mapping to human chromosome 18. Chromosome 18 houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. |
| Gene ID | 80323 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 68, Cutaneous T-cell lymphoma-associated antigen se57-1, CTCL-associated antigen se57-1, CCDC68 |
| Target/Specificity | Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL). |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CCDC68 |
|---|---|
| Function | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localizes to the subdistal appendages of centrioles (PubMed:28422092). |
| Tissue Location | Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL) |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP58864
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