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CLEC 4E Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9ULY5 |
| Reactivity | Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25073 Da |
| Gene ID | 26253 |
|---|---|
| Other Names | C-type lectin domain family 4 member E, C-type lectin superfamily member 9, Macrophage-inducible C-type lectin, MINCLE, CLEC4E {ECO:0000303|PubMed:24101491, ECO:0000312|HGNC:HGNC:14555} |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,Flow Cyt=5 µg/Test,IF=1:50-200, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CLEC4E {ECO:0000303|PubMed:24101491, ECO:0000312|HGNC:HGNC:14555} |
|---|---|
| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage- associated molecular patterns (DAMPs) of abnormal self and pathogen- associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T- cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9R0Q8} |
| Tissue Location | Expressed in monocytes and macrophages. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP59030
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