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CLEC4E Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a full length recombinant CLEC4E.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9ULY5 |
| Other Accession | BC000715 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2D12 |
| Calculated MW | 25073 Da |
| Gene ID | 26253 |
|---|---|
| Other Names | C-type lectin domain family 4 member E, C-type lectin superfamily member 9, Macrophage-inducible C-type lectin, CLEC4E, CLECSF9, MINCLE |
| Target/Specificity | CLEC4E (AAH00715, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLEC4E Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
References
1.Mincle and human B cell function.Kawata K, Illarionov P, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Eric Gershwin M.J Autoimmun. 2012 Jun 12.2.Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans.Bugarcic A, Hitchens K, Beckhouse AG, Wells CA, Ashman RB, Blanchard H.Glycobiology. 2008 Sep;18(9):679-85. Epub 2008 May 28.
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