C19orf28 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q6NUT3 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 52075 Da |
Gene ID | 126321 |
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Other Names | Major facilitator superfamily domain-containing protein 12, MFSD12 {ECO:0000303|PubMed:29025994, ECO:0000312|HGNC:HGNC:28299} |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | MFSD12 {ECO:0000303|PubMed:29025994, ECO:0000312|HGNC:HGNC:28299} |
---|---|
Function | Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952, PubMed:37751742). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis (PubMed:33208952, PubMed:37751742). |
Cellular Location | Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed, with high expression in primary melanocytes. |
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