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Anti-EPHA3 Antibody
Rabbit polyclonal antibody to EPHA3
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P29320 |
| Other Accession | P29319 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Chicken, Bovine, Drosophila |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110131 Da |
| Gene ID | 2042 |
|---|---|
| Other Names | ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1 |
| Target/Specificity | Recognizes endogenous levels of EPHA3 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | EPHA3 |
|---|---|
| Synonyms | ETK, ETK1, HEK, TYRO4 |
| Function | Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Widely expressed. Highest level in placenta. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EPHA3. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP59547
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