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Anti-TESK1 Antibody
Rabbit polyclonal antibody to TESK1
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q15569 |
| Reactivity | Human, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67684 Da |
| Gene ID | 7016 |
|---|---|
| Other Names | Dual specificity testis-specific protein kinase 1; Testicular protein kinase 1 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TESK1. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000), IP (1/10 - 1/100) IP~~N/A |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TESK1 |
|---|---|
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin- mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63572} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q63572}. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (PubMed:15584898). Localized to F- actin-rich lamellipodia at the cell periphery following fibronectin- mediated cell adhesion of Schwann cells (By similarity) {ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898} |
| Tissue Location | Expressed in podocytes and renal tubular cells in the kidney (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TESK1. The exact sequence is proprietary.
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$ 195.00
$ 385.00
Cat# AP59715
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