|Reactivity||Human, Mouse, Rat|
|Calculated MW||23012 Da|
|Other Names||DNA dC->dU-editing enzyme APOBEC-3A; A3A; Phorbolin-1|
|Target/Specificity||Recognizes endogenous levels of APOBEC3A protein.|
|Dilution||WB~~WB (1/500 - 1/1000)|
|Format||Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.|
|Cellular Location||Nucleus. Cytoplasm.|
|Tissue Location||Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non- lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.|
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Provided below are standard protocols that you may find useful for product applications.
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human APOBEC3A. The exact sequence is proprietary.
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