Anti-CLK1 Antibody
Rabbit polyclonal antibody to CLK1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF/IC, IHC |
---|---|
Primary Accession | P49759 |
Other Accession | P22518 |
Reactivity | Human, Mouse, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 57291 Da |
Gene ID | 1195 |
---|---|
Other Names | CLK; Dual specificity protein kinase CLK1; CDC-like kinase 1 |
Target/Specificity | Recognizes endogenous levels of CLK1 protein. |
Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | CLK1 (HGNC:2068) |
---|---|
Synonyms | CLK |
Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P22518}. |
Tissue Location | Endothelial cells.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CLK1. The exact sequence is proprietary.
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