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Anti-FRS2 (pY436) Antibody
Rabbit polyclonal antibody to FRS2 (pY436)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q8WU20 |
| Other Accession | Q8C180 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57029 Da |
| Gene ID | 10818 |
|---|---|
| Other Names | Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1 |
| Target/Specificity | Recognizes endogenous levels of FRS2 (pY436) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | FRS2 |
|---|---|
| Function | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. |
| Cellular Location | Endomembrane system. Note=Cytoplasmic, membrane- bound |
| Tissue Location | Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human FRS2 (pY436). The exact sequence is proprietary.
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