Anti-GNL3L Antibody
Rabbit polyclonal antibody to GNL3L
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
---|---|
Primary Accession | Q9NVN8 |
Other Accession | Q6PGG6 |
Reactivity | Human, Mouse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 65573 Da |
Gene ID | 54552 |
---|---|
Other Names | Guanine nucleotide-binding protein-like 3-like protein |
Target/Specificity | Recognizes endogenous levels of GNL3L protein. |
Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | GNL3L |
---|---|
Function | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. |
Cellular Location | Nucleus, nucleolus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GNL3L. The exact sequence is proprietary.
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