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Anti-DNA Polymerase gamma 2 Antibody
Rabbit polyclonal antibody to DNA Polymerase gamma 2
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UHN1 |
| Other Accession | Q9QZM2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54911 Da |
| Gene ID | 11232 |
|---|---|
| Other Names | MTPOLB; DNA polymerase subunit gamma-2 mitochondrial; DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DNA Polymerase gamma 2. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IHC~~1:100~500 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | POLG2 {ECO:0000303|PubMed:30157269, ECO:0000312|HGNC:HGNC:9180} |
|---|---|
| Function | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:P54098}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:P54098} |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DNA Polymerase gamma 2. The exact sequence is proprietary.
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