Anti-PTP1B (pS50) Antibody
Rabbit polyclonal antibody to PTP1B (pS50)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | P18031 |
Other Accession | P35821 |
Reactivity | Human, Mouse, Rat, Zebrafish, Monkey, Pig, Chicken, Drosophila |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 49967 Da |
Gene ID | 5770 |
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Other Names | PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B |
Target/Specificity | Recognizes endogenous levels of PTP1B (pS50) protein. |
Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | PTPN1 |
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Synonyms | PTP1B |
Function | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. |
Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=Interacts with EPHA3 at the cell membrane |
Tissue Location | Expressed in keratinocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PTP1B (pS50). The exact sequence is proprietary.
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