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Anti-DOCK2 Antibody
Rabbit polyclonal antibody to DOCK2
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q92608 |
| Other Accession | Q8C3J5 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 211948 Da |
| Gene ID | 1794 |
|---|---|
| Other Names | KIAA0209; Dedicator of cytokinesis protein 2 |
| Target/Specificity | Recognizes endogenous levels of DOCK2 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/50 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | DOCK2 |
|---|---|
| Synonyms | KIAA0209 |
| Function | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. |
| Cellular Location | Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin |
| Tissue Location | Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DOCK2. The exact sequence is proprietary.
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