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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NMBR Antibody
Anti-NMBR Antibody
Rabbit polyclonal antibody to NMBR
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IF/IC |
|---|---|
| Primary Accession | P28336 |
| Other Accession | O54799 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43435 Da |
| Gene ID | 4829 |
|---|---|
| Other Names | Neuromedin-B receptor; NMB-R; Epididymis tissue protein Li 185a; Neuromedin-B-preferring bombesin receptor |
| Target/Specificity | Recognizes endogenous levels of NMBR protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | NMBR |
|---|---|
| Function | Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre- Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR- expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in epididymis (at protein level). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NMBR. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP61356
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