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TOMM70A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TOMM70A Antibody (C-term) AP6745b
    Western blot analysis of TOMM70A antibody (C-term) (Cat. #AP6745b) in HL60 cell line lysates (35ug/lane). TOMM70A (arrow) was detected using the purified Pab.
    detail
  • IHC-P - TOMM70A Antibody (C-term) AP6745b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with TOMM70A Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - TOMM70A Antibody (C-term) AP6745b
    Flow cytometric analysis of hela cells using TOMM70A Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession O94826
Other Accession Q75Q39, Q9CZW5
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 67455 Da
Antigen Region 579-608 aa
Additional Information
Gene ID 9868
Other Names Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70
Target/Specificity This TOMM70A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-608 amino acids from the C-terminal region of human TOMM70A.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTOMM70A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOMM70 (HGNC:11985)
Function Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein
Research Areas
Citations ( 0 )

Background

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.

References

Blesa,J.R., Gene 427 (1-2), 58-64 (2008)
Chou,C.H., Mol. Biol. Cell 17 (9), 3952-3963 (2006)
Edmonson,A.M., Cell Commun. Adhes. 9 (1), 15-27 (2002)

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$ 182.50
$ 70.00
Cat# AP6745b
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