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TPH1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P17752 |
| Other Accession | Q92142, P09810, P17290, P70080 |
| Reactivity | Human |
| Predicted | Chicken, Rabbit, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50985 Da |
| Antigen Region | 35-62 aa |
| Gene ID | 7166 |
|---|---|
| Other Names | Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPH1, TPH, TPRH, TRPH |
| Target/Specificity | This TPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human TPH1. |
| Dilution | IF~~1:10~50 FC~~1:10~50 IHC-P~~1:50~100 WB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TPH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPH1 |
|---|---|
| Synonyms | TPH, TPRH, TRPH |
| Function | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate- determining step of serotonin biosynthesis. |
| Tissue Location | [Isoform 2]: Seems to be less widely expressed than isoform 1. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TPH1 is a member of the aromatic amino acid hydroxylase family. This protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter.
References
Johansson,T.A., et.al., BMC Cancer 9, 321 (2009)
Kuhn,D.M., et.al., J. Neurochem. 68 (5), 2220-2223 (1997)
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