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G3BP2 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UN86 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54121 Da |
| Gene ID | 9908 |
|---|---|
| Other Names | G3BP2; KIAA0660; Ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | G3BP2 {ECO:0000303|PubMed:23279204, ECO:0000312|HGNC:HGNC:30291} |
|---|---|
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, Stress granule |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Probable scaffold protein that may be involved in mRNA transport.
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$ 350.00
Cat# AP69992
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