GPR50 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF |
---|---|
Primary Accession | Q13585 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 67369 Da |
Gene ID | 9248 |
---|---|
Other Names | GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9 |
Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | GPR50 |
---|---|
Function | G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (PubMed:19699797). Promotes self- renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation (PubMed:21858214). Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (PubMed:29572483). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic density |
Tissue Location | Hypothalamus and pituitary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Does not bind melatonin.
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