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PANK1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8TE04 |
| Other Accession | Q8K4K6 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64339 Da |
| Antigen Region | 332-360 aa |
| Gene ID | 53354 |
|---|---|
| Other Names | Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1, PANK1, PANK |
| Target/Specificity | This PANK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-360 amino acids from the Central region of human PANK1. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PANK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PANK1 |
|---|---|
| Synonyms | PANK |
| Function | [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. |
| Cellular Location | Cytoplasm. [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome |
| Tissue Location | [Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.
References
Ramaswamy, G., et al., J. Lipid Res. 45(1):17-31 (2004).
Ni, X., et al., Int. J. Biochem. Cell Biol. 34(2):109-115 (2002).
Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).
Westaway, S.K., et al., Int. J. Biochem. Cell Biol. 34 (12), 1629 (2002) (): ().
Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().
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