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PHB2 Antibody (Y128)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PHB2 Antibody (Y128) AP7270d
    Western blot analysis of PHB2-Y128(Cat. #AP7270d) in mouse NIH-3T3 cell line lysates (35ug/lane).PHB2 (arrow) was detected using the purified Pab.
  • WB - PHB2 Antibody (Y128) AP7270d
    All lanes : Anti-Phospho-PHB2-Y128. ctrl at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: 293 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - PHB2 Antibody (Y128) AP7270d
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PHB2 Antibody (Y128) (Cat.#AP7270d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99623
Other Accession Q5XIH7, O35129, Q5ZMN3, Q2HJ97, NP_009204
Reactivity Human, Mouse
Predicted Bovine, Chicken, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33296 Da
Antigen Region 106-134 aa
Additional Information
Gene ID 11331
Other Names Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH147661, ECO:0000312|HGNC:HGNC:30306}
Target/Specificity This PHB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from human PHB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHB2 Antibody (Y128) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
Cellular Location Mitochondrion inner membrane. Cytoplasm. Nucleus. Cell membrane [Isoform 2]: Mitochondrion inner membrane
Research Areas
Citations (0)

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PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.


Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007)
Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)

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$ 350.00
$ 117.00
Cat# AP7270d
Availability: In Stock
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