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NP1(Nptx1) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NP1(Nptx1) Antibody (C-term) AP7272b
    Western blot analysis of Nptx1 Antibody (C-term) in 293 cell line lysates (35ug/lane). Nptx1 (arrow) was detected using the purified Pab.
  • IHC-P - NP1(Nptx1) Antibody (C-term) AP7272b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with Nptx1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q15818
Other Accession Q62443, P47971
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 364-393 aa
Additional Information
Other Names Neuronal pentraxin-1, NP1, 47 kDa taipoxin-binding protein, Neuronal pentraxin I, NP-I, Nptx1
Target/Specificity This NP1(Nptx1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human NP1(Nptx1).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNP1(Nptx1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPTX1
Function May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
Cellular Location Cytoplasmic vesicle, secretory vesicle EMBL; U61849; AAC50727.1; -; mRNA EMBL; AK127335; BAG54485.1; -; mRNA EMBL; BC089441; AAH89441.1; -; mRNA CCDS; CCDS32762.1; - RefSeq; NP_002513.2; NM_002522.3 SMR; Q15818; - BioGRID; 110944; 47 IntAct; Q15818; 36 MINT; Q15818; - STRING; 9606.ENSP00000307549; - TCDB; 1.C.92.1.3; the pentraxin (pentraxin) family iPTMnet; Q15818; - PhosphoSitePlus; Q15818; - BioMuta; NPTX1; - DMDM; 77416871; - EPD; Q15818; - jPOST; Q15818; - MassIVE; Q15818; - MaxQB; Q15818; - PaxDb; Q15818; - PeptideAtlas; Q15818; - PRIDE; Q15818; - ProteomicsDB; 60774; - Antibodypedia; 32766; 380 antibodies DNASU; 4884; - Ensembl; ENST00000306773; ENSP00000307549; ENSG00000171246 GeneID; 4884; - KEGG; hsa:4884; - UCSC; uc002jyp.2; human CTD; 4884; - DisGeNET; 4884; - EuPathDB; HostDB:ENSG00000171246.5; - GeneCards; NPTX1; - HGNC; HGNC:7952; NPTX1 HPA; ENSG00000171246; Tissue enriched (brain) MIM; 602367; gene neXtProt; NX_Q15818; - OpenTargets; ENSG00000171246; - PharmGKB; PA31738; - eggNOG; ENOG410IFFF; Eukaryota eggNOG; ENOG410XR4W; LUCA GeneTree; ENSGT00990000203576; - HOGENOM; CLU_032051_0_0_1; - InParanoid; Q15818; - OMA; FGQTRFI; - OrthoDB; 770812at2759; - PhylomeDB; Q15818; - TreeFam; TF330208; - BioGRID-ORCS; 4884; 1 hit in 786 CRISPR screens ChiTaRS; NPTX1; human GeneWiki; NPTX1; - GenomeRNAi; 4884; - Pharos; Q15818; Tbio PRO; PR:Q15818; - Proteomes; UP000005640; Chromosome 17 RNAct; Q15818; protein Bgee; ENSG00000171246; Expressed in cerebellum and 180 other tissues Genevisible; Q15818; HS GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO GO; GO:0043005; C:neuron projection; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IBA:GO_Central GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0060385; P:axonogenesis involved in innervation; IBA:GO_Central GO; GO:0007417; P:central nervous system development; TAS:ProtInc GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; IDA:SynGO CDD; cd00152; PTX; 1 InterPro; IPR013320; ConA-like_dom_sf InterPro; IPR030476; Pentaxin_CS InterPro; IPR001759; Pentraxin-related Pfam; PF00354; Pentaxin; 1 PRINTS; PR00895; PENTAXIN SMART; SM00159; PTX; 1 SUPFAM; SSF49899; SSF49899; 1 PROSITE; PS00289; PTX_1; 1 PROSITE; PS51828; PTX_2; 1 2: Evidence at transcript level; Calcium; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Metal-binding; Reference proteome; Signal SIGNAL 1..22 /evidence="ECO:0000255" CHAIN 23..432 /note="Neuronal pentraxin-1" /id="PRO_0000023547" DOMAIN 226..428 /note="Pentraxin (PTX)" /evidence="ECO:0000255|PROSITE-ProRule:PRU01172" METAL 280 /note="Calcium 1" /evidence="ECO:0000250" METAL 358 /note="Calcium 1" /evidence="ECO:0000250" METAL 358 /note="Calcium 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU01172" METAL 359 /note="Calcium 1; via carbonyl oxygen" /evidence="ECO:0000250" METAL 360 /note="Calcium 1" /evidence="ECO:0000250" METAL 360 /note="Calcium 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU01172" METAL 370 /note="Calcium 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU01172" CARBOHYD 154 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 193 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" DISULFID 256..316 /evidence="ECO:0000255|PROSITE-ProRule:PRU01172" CONFLICT 7 /note="Missing (in Ref. 1; AAC50727)" /evidence="ECO:0000305" CONFLICT 20..22 /note="AGA -> P (in Ref. 1; AAC50727)" /evidence="ECO:0000305" CONFLICT 57 /note="S -> SN (in Ref. 1; AAC50727)" /evidence="ECO:0000305" CONFLICT 192 /note="R -> K (in Ref. 1; AAC50727)" /evidence="ECO:0000305" SEQUENCE 432 AA; 47122 MW; B881AC19F7C8F74A CRC64; MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
Research Areas
Citations (0)

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Background

NPTX1 is a member of the neuronal pentraxin gene family. Human neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin.

References

Hossain,M.A., J. Neurosci. 24 (17), 4187-4196 (2004)
Schlimgen,A.K., Neuron 14 (3), 519-526 (1995)

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Cat# AP7272b
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