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ADAMTS13 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q76LX8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 153604 Da |
| Antigen Region | 829-858 aa |
| Gene ID | 11093 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8 |
| Target/Specificity | This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13. |
| Dilution | WB~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAMTS13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS13 |
|---|---|
| Synonyms | C9orf8 |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. |
| Cellular Location | Secreted. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats |
| Tissue Location | Plasma. Expressed primarily in liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
References
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)
Levy G.G., Nichols W.C.Nature 413:488-494(2001)
Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002)
Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)
Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)
Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)
Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)
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