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ATP Synthase C Rabbit mAb
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- CITATIONS
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- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P05496 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 14277 Da |
| Gene ID | 516 |
|---|---|
| Other Names | ATP5MC1 |
| Dilution | WB~~1/500-1/1000 ICC~~N/A |
| Format | Liquid |
| Name | ATP5MC1 (HGNC:841) |
|---|---|
| Function | Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT- ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix (PubMed:37244256). Protons are taken up via the inlet half- channel and released through the outlet half-channel, following a Grotthuss mechanism (PubMed:37244256). |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
Research Areas
Citations (0)
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$ 385.00
Cat# AP74845
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