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Desmocollin 3 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q14574 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 99969 Da |
| Gene ID | 1825 |
|---|---|
| Other Names | DSC3 |
| Dilution | WB~~1/500-1/1000 ICC~~N/A |
| Format | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | DSC3 |
|---|---|
| Synonyms | CDHF3, DSC4 |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome {ECO:0000250|UniProtKB:P55850} Cytoplasm {ECO:0000250|UniProtKB:P55850}. Note=Expressed in the cytoplasm and at the cell membrane of oocytes {ECO:0000250|UniProtKB:P55850} |
| Tissue Location | Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567, PubMed:7665906). Also expressed in the buccal mucosa, esophagus and cervix (at protein level) (PubMed:7665906) |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP74874
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