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INPP4B Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O15327 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 104738 Da |
| Gene ID | 8821 |
|---|---|
| Other Names | INPP4B |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | INPP4B |
|---|---|
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). |
| Tissue Location | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75621
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