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ATP6V1A Rabbit mAb
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Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | P38606 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 68304 Da |
| Gene ID | 523 |
|---|---|
| Other Names | ATP6V1A |
| Dilution | WB~~1/500-1/1000 IHC-P~~N/A IP~~1/20 |
| Format | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | ATP6V1A |
|---|---|
| Synonyms | ATP6A1, ATP6V1A1, VPP2 |
| Function | Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50516}. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404}; Peripheral membrane protein. Lysosome {ECO:0000250|UniProtKB:P50516} Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines. |
| Tissue Location | High expression in the skin. |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP76399
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