Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
LTBP1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14766 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 186796 Da |
| Antigen Region | 1493-1525 aa |
| Gene ID | 4052 |
|---|---|
| Other Names | Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta1-BP-1, LTBP1 |
| Target/Specificity | This LTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1493-1525 amino acids from the C-terminal region of human LTBP1. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LTBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTBP1 (HGNC:6714) |
|---|---|
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in the aorta (at protein level) (PubMed:17293099). Isoform Long: Expressed in fibroblasts (PubMed:17293099). |
Provided below are standard protocols that you may find useful for product applications.
Background
LTBP1 may be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. This protein may play critical roles in controlling and directing the activity of TGFB1, and it may have a structural role in the extra cellular matrix (ECM).
References
Olofsson A., J. Biol. Chem. 270:31294-31297(1995)
Kanzaki T., Cell 61:1051-1061(1990)
Isogai Z., J. Biol. Chem. 278:2750-2757(2003)
Oklu R., Biochem. J. 352:601-610(2000)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
