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SGK2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9HBY8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41175 Da |
| Antigen Region | 395-426 aa |
| Gene ID | 10110 |
|---|---|
| Other Names | Serine/threonine-protein kinase Sgk2, Serum/glucocorticoid-regulated kinase 2, SGK2 |
| Target/Specificity | This SGK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-426 amino acids from the C-terminal region of human SGK2. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SGK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SGK2 |
|---|---|
| Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in liver, kidney and pancreas, and at lower levels in brain. |
Provided below are standard protocols that you may find useful for product applications.
Background
SGK2, a Ser/Thr protein kinase, is similar to serum- and glucocorticoid-induced protein kinase (SGK), but this gene product is not induced by serum or glucocorticoids. Expression is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK.
References
Friedrich, B., et al., Pflugers Arch. 445(6):693-696 (2003).
Embark, H.M., et al., Pflugers Arch. 445(5):601-606 (2003).
Gamper, N., et al., Pflugers Arch. 445(1):60-66 (2002).
Lang, F., et al., Sci. STKE 2001 (108), RE17 (2001).
Kobayashi, T., et al., Biochem. J. 344 Pt 1, 189-197 (1999).
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