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ITPKA Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23677 |
| Other Accession | NP_002211 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51009 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 3706 |
|---|---|
| Other Names | Inositol-trisphosphate 3-kinase A, Inositol 1, 5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A, ITPKA |
| Target/Specificity | This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ITPKA. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ITPKA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITPKA (HGNC:6178) |
|---|---|
| Function | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Expressed in brain.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
References
Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004).
Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002).
Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001).
Communi, D., et al., EMBO J. 16(8):1943-1952 (1997).
Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).
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