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MVP Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q03426 |
| Other Accession | NP_000422 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42451 Da |
| Antigen Region | 17-47 aa |
| Gene ID | 4598 |
|---|---|
| Other Names | Mevalonate kinase, MK, MVK |
| Target/Specificity | This MVK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human MVK. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MVP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MVK (HGNC:7530) |
|---|---|
| Function | Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419). |
| Cellular Location | Cytoplasm. Peroxisome {ECO:0000250|UniProtKB:P17256} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.
References
Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).
Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).
Simon, A., et al., Neurology 62(6):994-997 (2004).
Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).
Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).
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