|Application ||FC, IHC-P, WB, E|
|Calculated MW||52085 Da|
|Antigen Region||99-126 aa|
|Other Names||Nucleotide exchange factor SIL1, BiP-associated protein, BAP, SIL1|
|Target/Specificity||This SIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-126 amino acids from the Central region of human SIL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.|
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Provided below are standard protocols that you may find useful for product applications.
SIL1 IS a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein.
Clark,H.F., ET.AL., Genome Res. 13 (10), 2265-2270 (2003)
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