|Application ||WB, IHC-P, E|
|Calculated MW||29665 Da|
|Antigen Region||1-30 aa|
|Other Names||Bridging integrator 3, BIN3|
|Target/Specificity||This BIN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BIN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BIN3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytokinesis and septation where it has a role in the localization of F-actin.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Ubiquitously expressed except in brain.|
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Provided below are standard protocols that you may find useful for product applications.
BIN3 is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.
Ren,G., et.al., Microbiol. Mol. Biol. Rev. 70 (1), 37-120 (2006)
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