|Application ||FC, WB, E|
|Other Accession||Q62688, Q3USB7|
|Calculated MW||122728 Da|
|Antigen Region||149-176 aa|
|Other Names||Inactive phospholipase C-like protein 1, PLC-L1, Phospholipase C-deleted in lung carcinoma, Phospholipase C-related but catalytically inactive protein, PRIP, PLCL1|
|Target/Specificity||This PLCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-176 amino acids from the N-terminal region of human PLCL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLCL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.|
|Tissue Location||Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.|
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PLCL1 is an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and sphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a nhibitor of PPP1C.
Liu,Y.Z., et.al., PLoS ONE 3 (9), E3160 (2008)
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