|Application ||FC, IHC-P, WB, E|
|Calculated MW||21418 Da|
|Antigen Region||128-155 aa|
|Other Names||Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX|
|Target/Specificity||This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 amino acids from the C-terminal region of human CBX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.|
|Cellular Location||Nucleus. Note=Unassociated with chromosomes during mitosis|
|Tissue Location||Expressed in all adult and embryonic tissues.|
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Provided below are standard protocols that you may find useful for product applications.
CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.
Aagaard,L., et.al., EMBO J. 18 (7), 1923-1938 (1999)
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