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Paxillin Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, ICC, IP |
|---|---|
| Primary Accession | P49023 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | Paired box protein Pax-1; PAX-1; PAXI; paxillin; paxillin alpha; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 64505 Da |
| Dilution | WB 1:500~1:1000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Paxillin |
| Description | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). PXN is a multi-domain cytoskeletal protein that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | PXN (HGNC:9718) |
|---|---|
| Function | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269|PubMed:23128389} |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 195.00
$ 385.00
Cat# AP90317
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